6533b822fe1ef96bd127cddc

RESEARCH PRODUCT

Toxicological and bioactivity evaluation of blackcurrant press cake, sea buckthorn leaves and bark from Scots pine and Norway spruce extracts under a green integrated approach

Pirjo MattilaLuciana AzevedoTytti SarjalaNora PapVarpu MarjomäkiAmanda Dos Santos LimaLiang ZhangPetri KilpeläinenAnderson S. Sant'anaDaniel GranatoMingchun WenJarkko HellströmBaoru YangPertti MarnillaDhanik ReshamwalaMarianna M. FurtadoMarina FidelisRisto Korpinen

subject

Antioxidantmedicine.medical_treatmentAnti-Inflammatory AgentsToxicologyAntioxidantschemistry.chemical_compoundRibesAnti-Infective AgentsCandida albicansHippophaeFood sciencenatural resources0303 health sciencesbiologyChemistrybioaktiiviset yhdisteetPinus sylvestris04 agricultural and veterinary sciencesGeneral Medicine040401 food scienceEnterovirus B HumanProanthocyanidinvisual_artPlant Barkvisual_art.visual_art_mediumkiertotalousBarkQuercetinEllagic acidfree radicalsMicrobial Sensitivity Testsvapaat radikaalit03 medical and health sciences0404 agricultural biotechnologyindustrial by-productsCell Line TumormedicineMaceration (wine)HumansPress cakebiomassa (teollisuus)Picea030304 developmental biologyantioksidantitantimikrobiset yhdisteetbioactive compoundsBacteriaPlant Extractscircular economyScots pineGreen Chemistry Technologybiology.organism_classificationluonnonaineetextraction technologiesPlant Leavesuuttosivutuotteetmyrkylliset aineetFood Science

description

Aqueous extracts from blackcurrant press cake (BC), Norway spruce bark (NS), Scots pine bark (SP), and sea buckthorn leaves (SB) were obtained using maceration and pressurized hot water and tested for their bioactivities. Maceration provided the extraction of higher dry matter contents, including total phenolics (TPC), anthocyanins, and condensed tannins, which also impacted higher antioxidant activity. NS and SB extracts presented the highest mean values of TPC and antioxidant activity. Individually, NS extract presented high contents of proanthocyanidins, resveratrol, and some phenolic acids. In contrast, SB contained a high concentration of ellagitannins, ellagic acid, and quercetin, explaining the antioxidant activity and antibacterial effects. SP and BC extracts had the lowest TPC and antioxidant activity. However, BC had strong antiviral efficacy, whereas SP can be considered a potential ingredient to inhibit α-amylase. Except for BC, the other extracts decreased reactive oxygen species (ROS) generation in HCT8 and A549 cells. Extracts did not inhibit the production of TNF-alpha in lipopolysaccharide-stimulated THP-1 macrophages but inhibited the ROS generation during the THP-1 cell respiratory burst. The recovery of antioxidant compounds from these by-products is incentivized for high value-added applications. peerReviewed

yearjournalcountryeditionlanguage
2021-07-01
http://urn.fi/URN:NBN:fi:jyu-202111105598