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RESEARCH PRODUCT
Selective targeting of PARP-1 zinc finger recognition domains with Au(III) organometallics
Margot N. WenzelSamuel M. Meier-menchesThomas L. WilliamsAngela CasiniEberard RämischGiampaolo Baronesubject
Materials Chemistry2506 Metals and AlloysStereochemistryPoly ADP ribose polymeraseSurfaces Coatings and FilmCeramics and Composite010402 general chemistryMass spectrometry01 natural sciencesMolecular mechanicsCatalysisCoordination complexAdductCatalysiMaterials Chemistrychemistry.chemical_classificationZinc finger010405 organic chemistryElectronic Optical and Magnetic MaterialChemistry (all)Metals and AlloysGeneral ChemistryAnticancer drug0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialschemistrySettore CHIM/03 - Chimica Generale E InorganicaCeramics and Composites2506description
The binding of Au(iii) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed to two types of zinc fingers. Notably, the cyclometallated Au-C^N complex was identified as the most selective candidate to disrupt the PARP-1 zinc finger domain, forming distinct adducts compared to the coordination compound Auphen.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-18 |