6533b822fe1ef96bd127ce51
RESEARCH PRODUCT
On the dimerization of the primitive tRNAs: implications in the origin of genetic code.
Juan A. Martı́nez GiménezRafael Tabarés Seisdedossubject
Statistics and ProbabilityGeneticsGeneral Immunology and MicrobiologyModels GeneticApplied MathematicsRNAAminoacylationGeneral MedicineBiologyGenetic codeenvironment and public healthGeneral Biochemistry Genetics and Molecular Biologyenzymes and coenzymes (carbohydrates)RNA TransferGenetic CodeModeling and SimulationTransfer RNAbacteriaAnimalsGeneral Agricultural and Biological SciencesDimerizationdescription
RNAs that catalyse their own aminoacylation have been recently selected in vitro. These findings support the notion that the primitive aminoacyl-tRNA synthetases may have been RNAs. In this paper, we propose a structural model for the first aminoacyl-tRNA synthetase consisting of an RNA complex formed between two primitive tRNA molecules through two intermolecular loop-strand interactions, and with implications in the origin of the genetic code.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-09-18 | Journal of theoretical biology |