6533b822fe1ef96bd127d545

RESEARCH PRODUCT

In-vitro Proteoglykansynthese in redifferenzierten Chondrozyten

William A. HortonAmy Lynn AulthouseM. Beck

subject

chemistry.chemical_compoundchemistryMonolayerType II collagenAgaroseMolecular biologyIn vitroType I collagen

description

Human chondrocytes growing in monolayer cultures de-differentiate and produce type I collagen. They re-differentiate and resume their in-vivo characteristics (including the production of type II collagen) when cultured in an agarose-gel. To characterize the modulated cells in more detail, biochemical studies were performed in chondrocytes suspended in agarose for 1 to 3 weeks.

yearjournalcountryeditionlanguage
1989-01-01
https://doi.org/10.1007/978-3-642-74770-0_23