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RESEARCH PRODUCT
Lipid peroxidation and nitric oxide metabolites in a group of subjects with obstructive sleep apnea syndrome.
Eugenia HoppsGregorio CaimiRosalia Lo PrestiMaria MontanaBaldassare CaninoCaterina Ursosubject
Malemedicine.medical_specialtyPhysiologyThiobarbituric acidobstructive sleep apnea syndrome030204 cardiovascular system & hematologyNitric OxideNitric oxideLipid peroxidation03 medical and health scienceschemistry.chemical_compound0302 clinical medicinestomatognathic systemnitric oxide metabolitePhysiology (medical)Internal medicineTBARSLipid peroxidation; nitric oxide metabolites; obstructive sleep apnea syndrome; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Nitric Oxide; Sleep Apnea Obstructive; Physiology; Hematology; Cardiology and Cardiovascular Medicine; Physiology (medical)MedicineHumansNOxSleep Apnea Obstructivebusiness.industryApneaHematologyMiddle Agedmedicine.diseasenervous system diseasesrespiratory tract diseasesObstructive sleep apneaEndocrinology030228 respiratory systemchemistryFemaleLipid Peroxidationmedicine.symptomCardiology and Cardiovascular MedicinebusinessHypopneaHumandescription
It is known that in OSAS the plasma lipid peroxidation has an opposite behavior in comparison with nitric oxide metabolites. In the re-examination of our survey of OSAS subjects we calculated the ratio between thiobarbituric acid reactive substances (TBARS) and nitric oxide metabolites (NOx) in relation to OSAS severity. The study has regarded 48 OSAS subjects subdivided in two subgroups according to the apnea/hypopnea index - AHI- (Low = 21 subjects with AHI30 and High = 27 subjects with AHI30). From the obtained data it is evident that the TBARS/NOx ratio is significantly higher in the H subgroup compared to L subgroup as well as this ratio is reduced in L subgroup in comparison with the whole group of OSAS subjects. In the entire group of OSAS subjects the TBARS/NOx ratio results positively correlated with AHI and ODI and inversely correlated with mSO2.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-10-21 | Clinical hemorheology and microcirculation |