6533b823fe1ef96bd127dfa8
RESEARCH PRODUCT
Sekundärer Immundefekt bei Niereninsuffizienz am Beispiel der Hepatitis B-Impfung
Hubert DumannHans KöhlerS. MeuerK H Meyer Zum Büschenfeldesubject
Hepatitisbusiness.industryInterleukinGeneral Medicinemedicine.diseaseMolecular medicineIn vitroVaccinationImmune systemIn vivoDrug DiscoveryImmunologyMolecular MedicineMedicinebusinessReceptorGenetics (clinical)description
In dialysis patients the immune response to hepatitis B-vaccination is greatly impaired. In vitro the non-responders show a failure of the monocytes to support the process of primary T-cell activation. This defect results in a lack of interleukin 2-production and an enhanced sensitivity of the interleukin-2 receptor system. Addition of low doses of interleukin-2 fully reconstitutes the deficient immune response in vitro. Furthermore, the local application of low dose interleukin-2 during a standard vaccination with 40 µg hepatitis B-vaccine normalizes the non-responder state in vivo.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1988-09-01 | Klinische Wochenschrift |