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RESEARCH PRODUCT

Ventricular structural changes in patients with sleep-disordered breathing (SDB) and myocardial infarction

subject

description

Obstructive sleep apnea (OSA) is associated with cardiovascular diseases. Aim: To analyze structural parameters of myocardial damage in patients presenting with acute coronary syndrome (ACS) and its relationship with OSA severity. Method: This is a prospective, observational study in patients with a first acute myocardial infarction (MI) treated by percutaneous coronary intervention (PCI). Cardiovascular magnetic resonance (CMR) studies were performed at 3 days and 6 months. Eligible patients underwent a polysomnography within 30 days after PCI. Quantitative data were expressed as mean±SD. Linear regression analysis was used to describe associations between infarct characteristics and OSA. Results: Twenty-seven patients (age 62.2±10.5) presenting with ACS were recruited. Based on AHI≥5, OSA was diagnosed in 20 patients (74%), whereas 14 (55%) had moderate or severe OSA (AHI≥15). No differences were found between non-OSA vs OSA patients according to age, BMI, gender, Epworth, EuroQol-5D, arterial hypertension, hyperlipidemia and diabetes, but in neck circumference (p=0.02). Variables associated with myocardial infarction, at 1 week and 6 months, related to AHI, are depicted in table 1. Conclusion: Patients with ACS and OSA (AHI≥15) seem to have better prognosis, according to parameters of myocardial damage. Funded by SVN/FNCV 2017 grant