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RESEARCH PRODUCT

Prevalence of fimA genotypes of Porphyromonas gingivalis and other periodontal bacteria in a Spanish population with chronic periodontitis

José Manuel Almerich-sillaFrancisco Dasí-fernándezJosé María Montiel-companyMiriam Puig-silla

subject

AdultMaleGenotypePeriodontal examinationDentistryOdontologíaMicrobiologyGingivitismedicineTannerella forsythiaHumansPeriodontologyGeneral DentistryPorphyromonas gingivalisPeriodontitisbiologybusiness.industryAggregatibacter actinomycetemcomitansTreponema denticolabiochemical phenomena metabolism and nutritionMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseasebiology.organism_classificationCiencias de la saludChronic periodontitisstomatognathic diseasesOtorhinolaryngologySpainUNESCO::CIENCIAS MÉDICASChronic PeriodontitisbacteriaSurgeryResearch-ArticleFemaleFimbriae Proteinsmedicine.symptombusinessPorphyromonas gingivalis

description

Objectives: The aim of this study was to determine the prevalence of the different fimA genotypes of Porphyromonas gingivalis in adult Spanish patients with chronic periodontitis, patients with gingivitis and periodontally healthy subjects, and the relationship between these genotypes and other periodontopathogenic bacteria. Study design: Samples of subgingival plaque were taken from 86 patients (33 with chronic periodontitis, 16 with gingivitis, and 37 periodontally healthy) in the course of a full periodontal examination. PCR was employed to determine the presence of the 6 fimA genotypes of Porphyromonas gingivalis (I-V and Ib) and of Aggregatibacter actinomycetemcomitans, Tannerella forsythia and Treponema denticola. Results: Porphyromonas gingivalis fimA genotypes II and Ib were present in significantly higher percentages in periodontal patients (39.4% and 12.1% respectively) than in healthy or gingivitis subjects. The prevalence of Tannerella forsythia, Treponema denticola , and Porphyromonas gingivalis fimA genotype IV was significantly higher in the group that presented bleeding greater than 30%. A positive correlation was found between Porphyromonas gingivalis fimA genotype IV and Treponema denticola . Conclusions: A strong association between Porphyromonas gingivalis fimA genotypes II and Ib and chronic periodontitis exists in the Spanish population. The most prevalent genotype in periodontal patients is II

yearjournalcountryeditionlanguage
2012-05-01Medicina Oral, Patología Oral y Cirugía Bucal
10.4317/medoral.17009http://europepmc.org/articles/PMC3505701