6533b823fe1ef96bd127e105
RESEARCH PRODUCT
Embryonic neural cell adhesion molecules on human natural killer cells
Matthias HusmannDieter Bitter-suermannTorsten PietschChristoph WeisgerberBernhard Fleischersubject
Antigens Differentiation T-LymphocyteCD3 ComplexCell Adhesion Molecules NeuronalT-LymphocytesCD3Blotting WesternImmunologyReceptors Antigen T-CellChromatography AffinityNatural killer cellCell–cell interactionmedicineHumansImmunology and AllergybiologyCell adhesion moleculeAntibodies MonoclonalCell migrationFlow CytometryPrecipitin TestsMolecular biologyEmbryonic stem cellCell biologyKiller Cells Naturalmedicine.anatomical_structurenervous systembiology.proteinNeural cell adhesion moleculeHoming (hematopoietic)description
The neural cell adhesion molecules (NCAM) are surface glycoproteins that were first described in brain tissue. NCAM mediate adhesion in a variety of cell-cell interactions. In the present study we show that the so-called "embryonic" NCAM, i.e., the highly polysialylated forms of these proteins, are expressed on natural killer cells and some CD3+ cells in man. Homotypic binding of NCAM, believed to be of importance for cell-cell adhesion in neural tissues, appears not to be essential for NK cell-mediated killing. Yet, NCAM might be involved in NK cell migration, homing or related functions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-09-01 | European Journal of Immunology |