6533b823fe1ef96bd127e122

RESEARCH PRODUCT

4-Aminopyridine and barium chloride attenuate the anti-epileptic effect of carbamazepine in hippocampal slices

A. HausdorfH. R. OlpeC. N. KolbHelmut L. Haas

subject

Malemedicine.medical_specialtyPotassium Channelsmedicine.medical_treatmentBarium CompoundsHippocampal formationHippocampusCellular and Molecular Neurosciencechemistry.chemical_compoundChloridesInternal medicinemedicineAnimals4-AminopyridineMode of actionMolecular BiologyPharmacologyEpilepsyChemistryBarium chloride4-AminopyridineCell BiologyCarbamazepinePotassium channelRatsElectrophysiologyCarbamazepineAnticonvulsantEndocrinologyMechanism of actionBariumDepression ChemicalMolecular MedicineAnticonvulsantsmedicine.symptommedicine.drug

description

The exact mode of action of the anti-epileptic agent carbamazepine is unknown. In hippocampal slices in which epileptiform discharges were induced by addition of penicillin to the perfusion medium, the depressant effect of carbamazepine was attenuated by the potassium-channel blockers barium chloride (0.1 mM) and 4-aminopyridine (200 microM), which suggested that potassium fluxes might be involved in the mechanism of action of carbamazepine.

yearjournalcountryeditionlanguage
1991-03-15Experientia
https://doi.org/10.1007/bf01958152