6533b823fe1ef96bd127e1dc

RESEARCH PRODUCT

Spirocurcasone, a diterpenoid with a novel carbon skeleton from Jatropha curcas.

Heinz C. SchröderOlapeju O. AiyelaagbePaolo LucianoWerner E.g. MüllerGiuseppina ChianeseOrazio Taglialatela-scafatiErnesto Fattorusso

subject

biologyPlant rootsMolecular StructureChemistryMouse LymphomaOrganic ChemistryCarbon skeletonJatrophaJatrophabiology.organism_classificationBiochemistryAntineoplastic Agents PhytogenicPlant RootsTerpenoidMicePlant BarkOrganic chemistryAnimalsPhysical and Theoretical ChemistryDiterpenesDrug Screening Assays AntitumorJatropha curcasSpirocurcasone

description

Spirocurcasone (14), a diterpenoid possessing the unprecedented "spirorhamnofolane" skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was established using HRESIMS, NMR, and quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum. Some of the isolated diterpenoids showed a potent activity against L5178Y, a mouse lymphoma cell line.

yearjournalcountryeditionlanguage
2010-12-09Organic letters
10.1021/ol102802uhttps://pubmed.ncbi.nlm.nih.gov/21141918