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RESEARCH PRODUCT
Resveratrol as a Gene Regulator in the Vasculature
Huige LiUlrich FörstermannNing Xiasubject
Anti-Inflammatory AgentsRegulatorPharmaceutical ScienceResveratrolBiologyAntioxidantschemistry.chemical_compoundSirtuin 1Downregulation and upregulationStilbenesGene expressionAnimalsHumansTranscription factorSirtuin 1food and beveragesCell biologyNitric oxide synthaseGene Expression RegulationchemistryBiochemistryResveratrolAcetylationbiology.proteinEndothelium VascularReactive Oxygen Specieshormones hormone substitutes and hormone antagonistsBiotechnologydescription
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) possesses multiple protective properties in the vasculature, including anti-oxidative and anti-inflammatory effects and improvement of endothelial function. A substantial part of these effects is attributable to gene expression changes induced by the compound. Resveratrol can activate the NAD-dependent deacetylase sirtuin 1 (SIRT1), leading to deacetylation of SIRT1 target molecules such as NF-kB and forkhead box O (FOXO) transcription factors. The inhibition of NF-kB by resveratrol reduces the expression of inflammation mediators. FOXO factors are implicated in the upregulation of antioxidant enzymes and the endothelial-type nitric oxide synthase. In addition, resveratrol upregulates a number of antioxidant enzymes by activating nuclear factor-E2-related factor-2 (Nrf2) and downregulates NADPH oxidases through yet known mechanisms.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-03-15 | Current Pharmaceutical Biotechnology |