6533b823fe1ef96bd127e2fb
RESEARCH PRODUCT
Diethylene glycol (DEG)-associated myocardial changes: a pilot investigation of chronic intoxication in guinea-pigs.
Bernd BrinkmannT. PetkovitsS. Ogbuihisubject
MalePathologymedicine.medical_specialtyGuinea PigsAdministration OralPilot ProjectsDistensionMitochondria HeartPathology and Forensic MedicineGuinea pigchemistry.chemical_compoundmedicineAnimalsMyocytolysisChemistryMyocardiumDiethylene glycolAnatomyHyperplasiamedicine.diseaseMicroscopy ElectronCoagulative necrosisPleomorphism (microbiology)Ethylene GlycolsMyofibrilCardiomyopathiesdescription
The myocardium of guinea pigs fed on sublethal doses of diethylene glycol (DEG) over a period of 2–11 days was examined for microscopical and ultrastructural changes. Coagulative myocytolysis and loss of myofibrils, not observed in the controls, was patchily distributed throughout the myocardium. The accompanying ultrastructural features included swelling, pleomorphism and hyperplasia of mitochondria with an associated distension of the interfibrillary spaces and a displacement, distortion and rupture of adjacent myofibrils.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-03-01 | International journal of legal medicine |