6533b823fe1ef96bd127e97e
RESEARCH PRODUCT
ChemInform Abstract: New Strategy for the Stereoselective Synthesis of Fluorinated β-Amino Acids.
Antonio NavarroEsther SalavertSantos FusteroBelén PinaAntonio Simon FuentesM. Carmen Ramírez De Arellanosubject
chemistry.chemical_classificationChiral auxiliarychemistry.chemical_compoundchemistryReducing agentChemical reductionOrganic chemistryStereoselectivityGeneral MedicineRedoxAmino aciddescription
Racemic and chiral nonracemic α-substituted and α-unsubstituted β-fluoroalkyl β-amino acid derivatives 6 and 9 have been synthesized in two steps starting from fluorinated imidoyl chlorides 1 and ester enolates. This approach is based on the chemical reduction of previously obtained γ-fluorinated β-enamino esters 4 by using ZnI2/NaBH4 in a nonchelated aprotic medium (dry CH2Cl2) as the reducing agent. A metal-chelated six-membered model has been suggested to explain the stereochemical outcome of the reduction reaction. The process takes place with high yields and with moderate to good diastereoselectivity. The best results related to diastereoselective reduction of chiral β-enamino esters 4 were provided by the use of (−)-8-phenylmenthol as a chiral auxiliary.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-18 | ChemInform |