6533b823fe1ef96bd127ea33

RESEARCH PRODUCT

Haemolytic-uraemic syndrome during severe lupus nephritis: efficacy of plasma exchange

Bernard BonnotteLaurent MartinV. LeguySabine BerthierMaxime SamsonBernard LorcerieNona JanikashviliSylvain Audia

subject

medicine.medical_specialtyThrombotic microangiopathyCyclophosphamidebusiness.industryAnemiaThrombotic thrombocytopenic purpuraLupus nephritismedicine.diseaseGastroenterologySchistocytePharmacotherapyimmune system diseaseshemic and lymphatic diseasesInternal medicineInternal MedicineMedicineskin and connective tissue diseasesbusinessAnti-SSA/Ro autoantibodiesmedicine.drug

description

Systemic lupus erythematosus (SLE) has been described as a cause of thrombotic microangiopathy, especially thrombotic thrombocytopenic purpura (TTP). Haemolytic-uraemic syndrome (HUS) is less frequent in SLE. We report a case of such an association during an episode of severe lupus nephritis in a young woman, who was successfully treated with steroids, cyclophosphamide and especially plasma exchange with plasma replacement. This report highlights the importance of recognising atypical HUS in SLE patients by looking for schistocytes in case of haemolytic anemia with a negative antiglobulin test, in order to begin plasma exchange.

yearjournalcountryeditionlanguage
2012-01-01Internal Medicine Journal
https://doi.org/10.1111/j.1445-5994.2011.02591.x