6533b823fe1ef96bd127ebc5

RESEARCH PRODUCT

Autoradiographic technique to assess distribution of blood flow within organs

H. FlohrH. FlohrA. HoppeA. Hoppe

subject

PhysiologyClinical BiochemistryKidneyRadioactive microspheresMicrosphereDogsPhysiology (medical)MethodsmedicineAnimalsDistribution (pharmacology)Serum Albumin Radio-IodinatedRenal circulationIsotopeChemistryBrainBlood flowHuman physiologyAnatomyCoronary Vesselsmedicine.anatomical_structureRegional Blood FlowVentricleCatsAutoradiographyRabbits

description

A method is described for assessing the distribution of blood flow within organs. Microspheres, 5–50 μ in diameter, labelled with a beta-emitting isotope were injected into the left ventricle of experimental animals. The distribution of the indicator within the tissues, which is assumed to represent the regional distribution of flow, was visualized and measured quantitatively by autoradiography. Local flow rates in areas of about 1,2 mm in diameter could be determined. Application of the technique for the study of regional myocardial and renal circulation is demonstrated.

yearjournalcountryeditionlanguage
1969-06-24Pfl�gers Archiv European Journal of Physiology
https://doi.org/10.1007/bf00586871