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RESEARCH PRODUCT

A Methanol Extract ofBrugmansia arboreaAffects the Reinforcing and Motor Effects of Morphine and Cocaine in Mice

María A. AguilarMarta Rodríguez-ariasManuel Daza-losadaVincenzo De FeoJosé MiñarroAntonio Bracci

subject

Article Subjectbiologybusiness.industryDopaminergiclcsh:Other systems of medicinePharmacologylcsh:RZ201-999biology.organism_classificationConditioned place preferenceComplementary and alternative medicineMechanism of actionBrugmansiaMorphinemedicineCholinergicMotor activitymedicine.symptombusinessCocaine abuseResearch Articlemedicine.drug

description

Previous reports have shown that several of the effects of morphine, including the development of tolerance and physical withdrawal symptoms, are reduced by extracts ofBrugmansia arborea(L.) Lagerheim (Solanaceae) (B. arborea). In the present study we evaluate the action of the methanol extract ofB. arborea(7.5–60 mg/kg) on the motor and reinforcing effects of morphine (20 and 40 mg/kg) and cocaine (25 mg/kg) using the conditioned place preference (CPP) procedure. At the doses employed,B. arboreadid not affect motor activity or induce any effect on CPP. The extract partially counteracted morphine-induced motor activity and completely blocked the CPP induced by 20 mg/kg morphine. On the other hand,B. arboreablocked cocaine-induced hyperactivity but did not block cocaine-induced CPP. Reinstatement of extinguished preference with a priming dose of morphine or cocaine was also inhibited byB. arborea. The complex mechanism of action ofB. arborea, which affects the dopaminergic and the cholinergic systems, seems to provide a neurobiological substrate for the effects observed. Considered as a whole, these results point toB. arboreaas a useful tool for the treatment of morphine or cocaine abuse.

yearjournalcountryeditionlanguage
2013-03-01Evidence-Based Complementary and Alternative Medicine
https://doi.org/10.1155/2013/482976