6533b823fe1ef96bd127ebf6

RESEARCH PRODUCT

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Lorenzo MemeoJayadev RajuAmedeo AmedeiDustin G. BrownRafaela Andrade-vieiraJordan WoodrickDale W. LairdFahd Al-mullaNeetu SinghGary S. GoldbergDebasish RoyRabeah Al-temaimiPaul DentWilliam H. BissonPaola A. MarignaniJan VondráčekGloria M. CalafGloria M. CalafRichard Ponce-cusiKarine A. Cohen-solalRiccardo Di FioreRita NahtaAnnamaria ColacciHosni SalemRobert C. CastellinoElizabeth P. RyanNichola CruickshanksHarini KrishnanChiara MondelloChristian C. NausMark WadeRabindra RoyMonica VaccariStefano ForteSarah N BayRoslida Abd HamidAhmed LasfarA. Ivana ScovassiRenza VentoRenza Vento

subject

Cancer ResearchReviewHazardous Substanceschemistry.chemical_compoundNeoplasmsAnimalsHumansMedicinebiologyAnimalbusiness.industryMedicine (all)Retinoblastoma proteinContact inhibitionCancerEnvironmental ExposureGeneral MedicineEnvironmental exposureEvasion (ethics)medicine.diseaseCell biologychemistryHazardous SubstanceImmunologyCancer cellbiology.proteinNeoplasmSignal transductionGrowth inhibitionbusinessHumanSignal Transduction

description

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.

yearjournalcountryeditionlanguage
2015-06-01Carcinogenesis
https://doi.org/10.1093/carcin/bgv028