6533b823fe1ef96bd127ec10

RESEARCH PRODUCT

Changes in Maternal Blood Inflammatory Markers As a Predictor Of Chorioamnionitis: A Prospective Multicenter Study

Mourad SedikiPaul SagotNicole LaurentNathalie LentzToufic HoyekIsabelle Le RayIsabelle Le RayMarc BardouDidier RiethmullerGuillaume MaceFrançoise GoirandFrançoise GoirandGilles SpagnoloFrédéric LirussiFrédéric LirussiRajeev Ramanah

subject

Adultmedicine.medical_specialtyPathologyImmunologyChorioamnionitisGastroenterologyLeukocyte CountObstetric Labor PrematurePredictive Value of TestsPregnancyInternal medicinemedicineHumansImmunology and AllergyPlacental CirculationAmnionProspective StudiesProspective cohort studyRupturePregnancybiologybusiness.industryC-reactive proteinArea under the curveObstetrics and GynecologyPrognosismedicine.diseaseC-Reactive ProteinChorioamnionitisReproductive MedicinePredictive value of testsbiology.proteinCytokinesGestationFemaleInflammation MediatorsbusinessPremature rupture of membranesBiomarkersFollow-Up Studies

description

Problem To evaluate the inflammatory pattern in maternal circulation from women with preterm premature rupture of membranes (PPROM) considering the occurrence of histologically confirmed chorioamnionitis (HCA). Method of study A prospective study was conducted in 121 women with PPROM between 24 and 34 + 0 weeks of gestation. Association between white blood cells (WBC) count, plasma CRP, IL-6, MCP-1 and IP-10 levels, and HCA was assessed. Results The rate of HCA was 44.7% (54/121). During the 5 days preceding delivery, median CRP, WBC, and IL-6 levels were significantly higher in the HCA than in no-HCA group (P < 0.001). Variations in IL-6, IP-10 levels, during the 24–72 hr before delivery, were predictors of the occurrence of HCA, but the diagnostic accuracy was low [Receiver Operating Characterictic (ROC) curve, area under the curve (AUC) = 0.56]. Conclusion An increase in IL-6, CRP, IP-10 maternal plasma levels was confirmed in PPROM women with HCA. Longitudinal follow-up of these markers did not add valuable information regarding HCA.

yearjournalcountryeditionlanguage
2014-07-22American Journal of Reproductive Immunology
https://doi.org/10.1111/aji.12323