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RESEARCH PRODUCT
Synthetic Tumor-Associated Glycopeptide Antigens from the Tandem Repeat Sequence of the Epithelial Mucin MUC4
Horst KunzConstanze Brockesubject
chemistry.chemical_classificationOrganic ChemistryMucinGeneral MedicineMolecular biologyCatalysisGlycopeptideAmino acidcarbohydrates (lipids)chemistry.chemical_compoundSolid-phase synthesisAntigenchemistryBiochemistryGalactosamineGlycosylThreonineGlycoproteindescription
In cancer research, the development of vaccines against tumor-associated antigens is of particular interest. Epithelial cells express mucin type glycoproteins, which are extensively O-glycosylated. In case of cancer, the expression of these mucins is increased, and their carbohydrate side chains show an aberrant glycosylation pattern. A set of single and double glycosylated hexadecapeptides representing the tandem repeat sequence of the epithelial mucin MUC4 carrying different tumor-associated carbohydrate antigens was prepared by sequential solid-phase glycopeptide synthesis. The crucial glycosyl amino acid building blocks containing the T N , T, sialyl-T N and (2,6)-sialyl-T antigens were synthesized according to a biomimetic strategy by stepwise extension of the saccharide side chain of a Fmoc-protected galactosamine threonine tert-butyl ester precursor.
year | journal | country | edition | language |
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2004-06-15 | Synthesis |