6533b823fe1ef96bd127ed70
RESEARCH PRODUCT
FISH screening of aneuploidies in preimplantation embryos to improve IVF outcome
José RemohíAntonio PellicerCarlos SimónLorena RodrigoCarmen RubioAmparo MercaderPilar BuendíaInmaculada Pérez-canoE. Mateusubject
AdultMaleInfertilityAbortion Habitualmedicine.medical_specialtyTime FactorsBiopsyAneuploidyFertilization in VitroBiologyAbortionPreimplantation genetic diagnosisChromosomesMale infertilityPregnancyRecurrent miscarriagemedicineHumansAdvanced maternal ageIn Situ Hybridization FluorescenceInfertility MaleChromosome AberrationsGynecologyPregnancyObstetricsPregnancy OutcomeObstetrics and GynecologyMiddle AgedAneuploidyEmbryo Mammalianmedicine.diseaseBlastocystTreatment OutcomeReproductive MedicineInfertilityFemaleInfertility FemaleMaternal AgeDevelopmental Biologydescription
Preimplantation genetic diagnosis (PGD) has transformed the approach to the infertility patient in the IVF setting. Although the principal applications of PGD have been to prevent the transmission of sex-linked diseases, in time and with growing knowledge of the chromosomal abnormalities observed in preimplantation embryos, its applications have widened. Nowadays, apart from its implications in the prevention of transmission of chromosomal and genetic abnormalities, PGD is being used with increased frequency to improve the IVF outcome in patients with advanced maternal age (or =38 years of age), recurrent miscarriage (or =2 miscarriages), recurrent IVF failure (or =3 failed IVF attempts) and severe male infertility. A high incidence of chromosomal abnormalities has been observed in these patient groups.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-11-09 | Reproductive BioMedicine Online |