6533b823fe1ef96bd127ed94
RESEARCH PRODUCT
A QSAR study investigating the potential anti-HIV-1 effect of some acyclovir and ganciclovir analogs
Antonino LauriaMarco TutoneAnna Maria Almericosubject
GanciclovirAnti hiv 1Quantitative structure–activity relationshipStereochemistryChemistryOrganic ChemistrymedicineQSAR neural network BMLR anti-HIV-1 activityvirus diseasesPharmacologySettore CHIM/08 - Chimica Farmaceuticamedicine.drugdescription
A QSAR study, involving the use of calculated physical-chemical properties (TSAR TM ), and the use of a neural network approach (TSAR TM ), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-06 |