6533b823fe1ef96bd127eddb
RESEARCH PRODUCT
Screening of oxazepine indole enantiomers by means of high performance liquid chromatography with imprinted polymer stationary phase.
Egidijus MachtejevasAudrius MaruškaPaul K. OwensBörje SellergrenVytas Martynaitissubject
Indole testchemistry.chemical_classificationModels MolecularMolecularly imprinted polymerFiltration and SeparationStereoisomerismPolymerHigh-performance liquid chromatographyAnalytical Chemistrychemistry.chemical_compoundOxazepineschemistryStationary phaseOrganic chemistryOxazepineIndicators and ReagentsEnantiomerMolecular imprintingChromatography High Pressure Liquiddescription
Chromatographic enantiomer separations of different oxazepine indole derivatives were performed using a molecularly imprinted polymer. A 5aR,12R,13S-trans-6,6-dimethyl-12,13-dihydro-6H-5a, 1 3-methanoindolo[2,1-b][1,3]naphthoxazepine-12-carboxamide enantiomerderivative was used as a template and the resultant polymer has shown enantiomer recognition for series of template related compounds. The mechanistic description of the chiral discrimination process is scrutinised, comparing the discrimination between the different conformations and substituents of the oxazepine indoles.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-09-01 | Journal of separation science |