0000000000241474

AUTHOR

Paul K. Owens

showing 3 related works from this author

Application of molecularly imprinted polymers in supercritical fluid chromatography

2000

Molecularly imprinted polymers (MIPs), for the templates free base racemic propranolol and the L-enantiomer of phenylalanine anilide (L-PA), were investigated as stationary phases in supercritical fluid chromatography (SFC). Large retention differences were observed on the propranolol MIP for both the template molecule and the structural analogue metoprolol compared to that observed on the corresponding blank polymer. Mobile phase composition and solute concentration were found to affect this retention behaviour. The phenylalanine anilide MIP (L-PA MIP) was found to be enantioselective in SFC with stronger retention observed for the template enantiomer. Throughout the study, characteristic …

chemistry.chemical_classificationChromatographyChromatographyPolymersOrganic ChemistryMolecularly imprinted polymerFree baseGeneral MedicinePolymerPropranololBiochemistryHigh-performance liquid chromatographySupercritical fluidAnalytical ChemistrychemistrySupercritical fluid chromatographyEnantiomerMolecular imprintingChromatography High Pressure LiquidJournal of Chromatography A
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Screening of oxazepine indole enantiomers by means of high performance liquid chromatography with imprinted polymer stationary phase.

2004

Chromatographic enantiomer separations of different oxazepine indole derivatives were performed using a molecularly imprinted polymer. A 5aR,12R,13S-trans-6,6-dimethyl-12,13-dihydro-6H-5a, 1 3-methanoindolo[2,1-b][1,3]naphthoxazepine-12-carboxamide enantiomerderivative was used as a template and the resultant polymer has shown enantiomer recognition for series of template related compounds. The mechanistic description of the chiral discrimination process is scrutinised, comparing the discrimination between the different conformations and substituents of the oxazepine indoles.

Indole testchemistry.chemical_classificationModels MolecularMolecularly imprinted polymerFiltration and SeparationStereoisomerismPolymerHigh-performance liquid chromatographyAnalytical Chemistrychemistry.chemical_compoundOxazepineschemistryStationary phaseOrganic chemistryOxazepineIndicators and ReagentsEnantiomerMolecular imprintingChromatography High Pressure LiquidJournal of separation science
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Evaluation of methods aimed at complete removal of template from molecularly imprinted polymers

2001

Polymers imprinted with clenbuterol were used to study the influence of various post-polymerization treatments [e.g., thermal annealing, microwave assisted extraction (MAE), Soxhlet extraction and supercritical fluid template desorption] on the bleeding of residual template. The aim of the study was to reduce the bleeding to levels that would allow the use of the materials as affinity phases for extraction of clenbuterol from bovine urine at concentrations below 1 ng ml−1. After treatment, the clenbuterol imprinted polymers were packed into solid-phase extraction columns and the bleeding was estimated by quantifying the amount of template released in 10 ml of methanol–acetic acid (9 + 1 v/v…

Formic acidENANTIOMERSCHROMATOGRAPHYBiochemistryAnalytical Chemistrychemistry.chemical_compoundElectrochemistrymedicineTrifluoroacetic acidSOLUTE RETENTIONEnvironmental ChemistrySolid phase extractionSpectroscopyChromatographyChemistryElutionExtraction (chemistry)Molecularly imprinted polymerSTATIONARY PHASESCHIRAL CAVITIESSupercritical fluidSOLID-PHASE EXTRACTIONRESOLUTIONClenbuterolENRICHMENTSORBENTmedicine.drug
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