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RESEARCH PRODUCT

Physical Activity Is Related with Cartilage Quality in Women with Knee Osteoarthritis

Miika T. NieminenIlkka KivirantaEveliina LammentaustaHannu KautiainenArja HäkkinenJuha PalonevaUrho M. KujalaMatti MunukkaAri HeinonenBenjamin Waller

subject

Cartilage ArticularSelf-Assessmentmedicine.medical_specialtynivelrikkoKnee Jointpolvetquantitative magnetic resonance imagingPhysical activitypostmenopausal womenPhysical Therapy Sports Therapy and RehabilitationrustoOsteoarthritisKnee Jointleisure-time physical activity03 medical and health sciences0302 clinical medicinemedicineBiochemical compositionHumansOrthopedics and Sports Medicineta315ExerciseVolunteerGlycosaminoglycans030203 arthritis & rheumatologyPostmenopausal womenbusiness.industryCartilageta3141Cardiorespiratory fitnessfollow-up study030229 sport sciencesMiddle AgedOsteoarthritis Kneemedicine.diseaseMagnetic Resonance Imagingcartilage compositionmedicine.anatomical_structureCardiorespiratory FitnessPhysical therapyMETFemaleseurantatutkimusbusinesshuman activitiesfyysinen aktiivisuusFollow-Up Studies

description

Purpose To study the relationship between 12-month leisure-time physical activity (LTPA) level and changes in estimated biochemical composition of tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis (OA). Methods Originally, 87 volunteer postmenopausal women, age 60 to 68 yr, with mild knee OA (Kellgren Lawrence I/II and knee pain) participated in a randomized controlled, 4-month aquatic training trial (RCT), after which 76 completed the 12-month postintervention follow-up period. Self-reported LTPA was collected along the 12-month period using a diary from which MET task hours per month were calculated. Participants were divided into MET task hour tertiles: 1, lowest (n = 25); 2 = middle (n = 25) and 3 = highest (n = 26). The biochemical composition of the cartilage was estimated using transverse relaxation time (T2) mapping sensitive to the properties of the collagen network and delayed gadolinium-enhanced magnetic resonance imaging of the cartilage (dGEMRIC index) sensitive to the cartilage glycosaminoglycan content. Secondary outcomes were cardiorespiratory fitness, isometric knee extension and flexion force, and the knee injury and OA outcome questionnaire. Results During the 12-month follow-up period, there was a significant linear relationship between higher LTPA level and increased dGEMRIC index changes in the posterior region of interest (ROI) of the lateral (P = 0.003 for linearity) and medial (P = 0.006) femoral cartilage. Furthermore, these changes were seen in the posterior lateral femoral cartilage superficial (P = 0.004) and deep (P = 0.007) ROI and in the posterior medial superficial ROI (P < 0.001). There was no linear relationship between LTPA level and other measured variables. Conclusions These results suggest that higher LTPA level is related to regional increases in estimated glycosaminoglycan content of tibiofemoral cartilage in postmenopausal women with mild knee OA as measured with dGEMRIC index during a 12-month period. peerReviewed

yearjournalcountryeditionlanguage
2017-01-01
http://urn.fi/URN:NBN:fi:jyu-201801151187