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RESEARCH PRODUCT

Synthesis, Characterization, and Saccharide Binding Studies of Bile Acid − Porphyrin Conjugates

Erkki KolehmainenVladimír KrálElina SievänenJuha Koivukorpi

subject

Spectrometry Mass Electrospray IonizationMagnetic Resonance SpectroscopyPorphyrinsmedicine.drug_classElectrospray ionizationCarbohydratesPharmaceutical ScienceESI MS.ArticleAnalytical ChemistryAbsorbanceBile Acids and Saltslcsh:QD241-441chemistry.chemical_compoundUltraviolet visible spectroscopylcsh:Organic chemistryHeterocyclic Compoundsvisible spectroscopyDrug Discoverymedicinepolycyclic compoundsOrganic chemistryPhysical and Theoretical ChemistrysaccharideAqueous solutionBile acidMolecular StructureOrganic Chemistry1H-NMRPorphyrinCombinatorial chemistryBile acidschemistryChemistry (miscellaneous)Proton NMRMolecular Medicinesense organsporphyrinConjugate

description

Synthesis and characterization of bile acid-porphyrin conjugates (BAPs) are reported. Binding of saccharides with BAPs in aqueous methanol was studied by monitoring changes in the visible absorption spectral of the porphyrin-moieties. Although these studies clearly showed absorbance changes, suggesting quite high if non-selective binding, the mass spectral studies do not unambiguously support these results.

yearjournalcountryeditionlanguage
2007-01-05Molecules
10.3390/12010013http://dx.doi.org/10.3390/12010013