6533b823fe1ef96bd127f42a

RESEARCH PRODUCT

Simulation and Parameter-Identification of the Closed-Loop Cardiovascular System by the Use of a Nonlinear Mathematical Model

subject

description

Abstract A non-linear model of human cardio-vascular system, which includes the short-term pressure regulation mechanism was mathematically derived and implemented on a PDP-11/45 in a block-oriented, interactive programming language. In this way the behaviour of the arterial and venous pressures, cardiac output, stroke volume, total peripheral resistance and heart-rate under ergometric workload was studied by simulation, and experimentally proved, that the model matches the system with good accuracy. In a second phase the parameters of the model were identified by the use of the output-error method. For this purpose a non-linear system identification programming package was applied. The parameter values, identified in this way are in good agreement with the relevant physiological data.