6533b823fe1ef96bd127f432

RESEARCH PRODUCT

Chapter 13 Antiphospholipid Antibodies and Vasculitis

Ronald A. AshersonPhilipp Von Landenberg

subject

Vascular diseasebusiness.industryDermatomyositismedicine.diseaseSclerodermaReview articleAntiphospholipid syndromeDiabetes mellitusRheumatoid arthritisImmunologymedicineskin and connective tissue diseasesbusinessVasculitis

description

Abstract Besides the large group of primary vasculitis diseases, vasculitis in autoimmune diseases is most commonly associated with systemic lupus erythematosus (SLE), scleroderma, rheumatoid arthritis, insulin-dependent diabetes mellitus, and dermatomyositis. The antiphospholipid syndrome (APS), as a relatively recently recognized autoimmune disorder, may also present with a variety of vasculitis features. These non-typical vasculitis syndromes have to be considered very carefully in the APS, and vasculitis manifestations presenting as systemic involvement in APS patients have to be identified very early to prevent patients from rapidly developing organ damage. The aim of this review article is to present the different manifestations of vasculitis in the APS and to give some suggestions about how to identify vasculitis or vasculopathy associated with the APS and the respective antiphospholipid antibodies.

https://doi.org/10.1016/s1571-5078(08)00413-3