6533b823fe1ef96bd127f450

RESEARCH PRODUCT

Selected Age-Related Disorders

subject

description

Aged human individuals are frequently affected by various age-related impairments and disorders at once (multimorbidity) making it difficult to investigate and understand the link between aging as key risk factor and single syndromes. In some chapters of this book links have been identified between molecular mechanisms of aging and the pathogenesis of human disorders in the elderly. Here, the focus is put on Alzheimers disease (AD) and cancer. While cancer in many cases can successfully be treated and sometimes even cured by pharmacology and/or surgery, AD is still an incurable deadly disease. Like almost no other disorder the onset of AD is strictly associated with higher age and experiences a strong increase in case numbers in our aging society. The authors are convinced that the actual causes of AD can only be identified when the biochemistry of the aging neuron is unraveled, especially in the context of well-known life-time risk factors.