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RESEARCH PRODUCT

Preliminary Findings: 25(OH)D Levels and PTH Are Indicators of Rapid Bone Accrual in Pubertal Children

Frances A. TylavskyLaura D CarboneJohn NorwoodKathryn M. RyderVicki M. ParkRongling LiSulin ChengCatherine Womack

subject

Malemedicine.medical_specialtyAdolescentBone accrualAcid PhosphataseRadioimmunoassayMedicine (miscellaneous)Parathyroid hormonechemistry.chemical_elementCalciumBone and BonesCohort StudiesAbsorptiometry PhotonBone DensityInternal medicineVitamin D and neurologymedicineHumansLongitudinal StudiesVitamin DChildDual-energy X-ray absorptiometryNutrition and DieteticsBone Density Conservation Agentsmedicine.diagnostic_testChemistryPubertyCalcium DietaryEndocrinologySocial ClassParathyroid HormoneDietary SupplementsCohortReceptors CalcitriolFemaleChild Nutritional Physiological PhenomenaBiomarkersCohort studyBone mass

description

The objective of this study was to evaluate the role of serum levels of 25(OH)D and PTH on the accumulation of whole body bone mass in a cohort of children.This was a longitudinal study (1.98 +/- 0.07 y) of sixty-nine children (89% Caucasian, 44% male) enrolled in a calcium supplementation trial. Bone area, bone mineral content (BMC) and density (BMD) of the whole body and radius were assessed using a QDR 2000 (Hologic, Inc) dual energy x-ray absorptiometer. Serum PTH and 25(OH)D were measured using radioimmunoassays.Vitamin D stores were inversely related gain in bone area (p0.002), BMC (p0.002) BMD (p0.027), as well as to PTH levels (p0.0001). Compared to those with adequate vitamin D stores (34 ng/ml), those who had consistently low vitamin D stores (18 ng/ml) had a 8% larger gain in bone area (p0.05); 11% in BMC (p0.05) and no differences in gain in BMD; after adjusting for baseline bone measurements, race, gender, season measured, Tanner stage, and calcium intake.High normal PTH with low-normal 25(OH)D stores and moderate to high calcium intake may be beneficial to accruing larger bone size and BMC during puberty.

yearjournalcountryeditionlanguage
2007-10-05Journal of the American College of Nutrition
https://doi.org/10.1080/07315724.2007.10719637