6533b823fe1ef96bd127f6c3
RESEARCH PRODUCT
Genetic contribution to alcohol dependence: Investigation of a heterogeneous german sample of individuals with alcohol dependence, chronic alcoholic pancreatitis, and alcohol-related cirrhosis
Stefan HermsWolfgang GaebelPer HoffmannCéline S. ReinboldNorbert DahmenJonas RosendahlUlla RoggenbuckBenedikt BrorsNorbert WodarzMarkus M. NöthenThomas BergMichael SoykaJana StrohmaierStephan BuchFelix StickelHelene DukalUlrich S. ZimmermannMonika RidingerMarcella RietschelSusanne LucaeJens TreutleinNorbert ScherbaumJosef FrankDilafruz JuraevaStefanie Heilmann-heimbachStephanie H. WittKarl MannBertram Müller-myhsokJochen HampeJerome C. FooKarl-heinz JöckelFranziska DegenhardtWolfgang MaierFabian StreitSven CichonRainer SpanagelMarcus IsingHenrike ScholzWolfgang H. SommerLiz RietschelFalk KieferAndreas J. Forstnersubject
0301 basic medicinemedicine.medical_specialtyCirrhosislcsh:QH426-470alcohol dependenceMedizinGenome-wide association studyLocus (genetics)610 Medicine & healthGastroenterologyArticle03 medical and health sciencesLiver diseaseInternal medicineGeneticsMedicine610 Medicine & healthAllele frequencyGenetics (clinical)genome-wide association studybusiness.industryAlcohol dependencealcohol dehydrogenaseADH1Bchronic alcoholic pancreatitisalcohol dependence; chronic alcoholic pancreatitis; alcoholic liver cirrhosis; genome-wide association study; alcohol dehydrogenase; <i>ADH1B</i>; <i>ADH1C</i>medicine.diseaseADH1CADH1Blcsh:Genetics030104 developmental biologyPancreatitisalcoholic liver cirrhosisbusinessdescription
The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus in a gene-based approach (puncorrected = 1.2 × 10-6; pcorrected = 0.020). This was driven by the AD subsample. No association with ADH1B was found in the combined ACP + ALC sample. On first inspection, this seems surprising, since ADH1B is a robustly replicated risk gene for AD and may therefore be expected to be associated also with subgroups of AD patients. The negative finding in the ACP + ALC sample, however, may reflect genetic stratification as well as random fluctuation of allele frequencies in the cases and controls, demonstrating the importance of large samples in which the phenotype is well assessed. OA gold
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-07-17 |