6533b823fe1ef96bd127f6d0
RESEARCH PRODUCT
Multimorbidity and polypharmacy in the elderly: Lessons from REPOSI
Pm MannucciA NobiliInvestigators ReposiM TettamantiL PasinaC FranchiF SalernoS CorraoA MarengoniM MarcuccimE SparacioS AlborghettiR Di CostanzoTk EldinM TettamantiCd DjadeD PriscoE SilvestriC CenciT BarniniC FirenzeG DelitalaS CartaS AtzoriG GuarnieriM ZanettiA SpallutiMg SerraMa BleveC PanicoM VanoliG GrignaniG CasellaL GasbarroneG ManiscalcoM GunelliD TirottaA BrucatoS GhidoniM BernardiS Li BassiL SantiG AgnelliA IorioM MarcucciE MarchesiniE MannarinoG LupattelliP RondelliF PaciulloF FabrisM CarlonF TurattoMc BaroniM ZardoR ManfrediniC MolinoM PalaF FabbianR NutiR ValentiM RuvioS CappelliG PaolissoMr RizzoMt LaietaM NutrizionaliT SalvatoreFc SassoR UtiliE Durante MangoniD PintoM InfettivologicaO OlivieriAm StanzialR FellinS VolpatoS FotiniM BarbagalloL DominguezL PlancesD D'angeloG RiniP MansuetoI PepeG LicataL CalvoM ValentiC BorghiE StrocchiEr RinaldiM ZoliE FabbriD MagalottiA AuteriAl PasquiL PuccettiFl PasiniPl CapecchiM BicchiC SabbaFs VellaA MarsegliaCv LuglioG PalascianoMe ModeoA AquilinoP RaffaeleS PuglieseC CapobiancoIa MurriA PostiglioneMr BarbellaF De StefanoL FenoglioC BrignoneC BraccoA GiraudoG MuscaO CuccurulloL CriccoA FiorentiniMd CappelliniG FabioS Seghezzi De Amicis MmS FargionP BonaraM BulgheroniR LombardiF MagriniF MassariT TonellaF PeyvandiA TedeschiR RossioG MoreoB FerrariL RoncariV MonzaniV SavojardoC FolliM MagniniD MariPd RossiS DamantiS ProloMs LilleriL CriccoA FiorentiniG MicaleM PoddaC SelmiF MedaF SalernoS AccordinoA ConcaV MontiGr CorazzaE MiceliMv LentiD PadulaCl BalduiniG BertolinoS ProviniF QuagliaG MurialdoM BovioF DallegriL OttonelloA QuercioliA BarrecaMb SecchiD GhelfiC BalsamoWs ChinL CarassaleS CaporotundoL AnastasioL SofiaM CarboneV ValentiaG TraisciL De FeudisS Di CarloG DavìMt GuagnanoS SestiliE BergamiE RizzioliC CagnoniL BertoneA ManucraP SoccorsoA BurattiT TogninNl LiberatoG BernasconiB NardoGb BianchiS GiaquintoG BenettiM QuaglioloGr CentenaroV PredabissiFrancesco PurrelloA Di PinoSalvatore PiroG MancusoD CalipariM BartoneF GulloM CortellaroM MagentaF PeregoMr MeroniM Cicardi Marina Magenta AgA SaccoA BonelliG DentamaroR RozziniL FalangaA GiordanoPc PerinB LorenzatiG GrudenG BrunoG MontrucchioE GrecoP TizzaniG Fera Di Luca MlD RennaA PerciccanteA CoralliR TassaraD MelisL RebellaG MenardoS BottoneE SferrazzoC FerriR StriuliR ScipioniR SalmiP GaudenziS GamberiniF RicciC MorabitoA SempliciniL GottardoG DelitalaS CartaS AtzoriG VendemialeG ServiddioR ForlanoL BolondiL RascitiI SerioC MasalaA MammarellaV RaparelliF Rossi FanelliM DelfinoA AmorosoF VioliS BasiliL PerriP SerraV FontanaM FalconeR LandolfiA GriecoA GalloG ZuccalàF FranceschiG De MarcoC ChiaraS MartaM BellusciD SettiF PedrazzoliG RomanelliC PiraliC AmoliniEa RoseiD RizzoniL CastoldiA PicardiUv GentilucciC MazzarelliP GalloL GuastiL CastiglioniA MarescaA SquizzatoS ContiniM MolaroG AnnoniM CorsiS ZazzettaM BertolottiC MussiR ScottoMa FerriF VeltriF ArturiE SuccurroG SestiU GualtieriSm GreciaF PerticoneA SciacquaM QueroC BagnatoP LoriaMa BecchiG MartucciA FantuzziM MaurantonioR CorinaldesiR De GiorgioM SerraV GrassoE RuggeriLm CarozzaF. Pignattisubject
Adverse drug effects; Aging; Drug prescription; Multidimensional evaluation; Multimorbidity; Polypharmacy; Aged; Aged; 80 and over; Female; Humans; Internal Medicine; Italy; Male; Registries; Societies; Medical; Comorbidity; Geriatrics; Polypharmacy; Internal Medicine; Emergency MedicineMalemedicine.medical_specialtyAgingmedia_common.quotation_subjectDrug prescriptionMEDLINEAdverse drug effects; Aging; Drug prescription; Multidimensional evaluation; Multimorbidity; Polypharmacy; Aged; Aged 80 and over; Female; Humans; Internal Medicine; Italy; Male; Registries; Societies Medical; Comorbidity; Geriatrics; Polypharmacy; Internal Medicine; Emergency MedicineDiseaseComorbidityAdverse drug effects; Aging; Drug prescription; Multidimensional evaluation; Multimorbidity; PolypharmacyelderlyAdverse drug effectsPromotion (rank)MedicalmedicineAdverse drug effect80 and overInternal MedicineHumansRegistriesMedical prescriptionmedia_commonAgedGeriatricsPolypharmacyAdverse drug effects; Aging; Drug prescription; Multidimensional evaluation; Multimorbidity; Polypharmacy; Emergency Medicine; Internal MedicineMultimorbidity Polypharmacy Aging Drug prescription Multidimensional evaluation Adverse drug effectsMultidimensional evaluationbusiness.industrySettore MED/09 - MEDICINA INTERNAMultimorbiditymedicine.diseaseComorbidityelderly multimorbidity polypharmacyClinical trialItalyGeriatricsFamily medicinePolypharmacyEmergency MedicineFemaleMedical emergencyAdverse drug effects; Aging; Drug prescription; Multidimensional evaluation; Multimorbidity; Polypharmacy; Internal Medicine; Emergency MedicinebusinessSocietiesmultimorbidity; polypharmacy; aging; drug prescription; multidimensional evaluation; adverse drug effectsMultimorbidity; Polypharmacy; Aging; Drug prescription; Multidimensional evaluationdescription
none 10 no The dramatic demographic changes that are occurring in the third millennium are modifying the mission of generalist professionals such as primary care physicians and internists. Multiple chronic diseases and the related prescription of multiple medications are becoming typical problems and present many challenges. Unfortunately, the available evidence regarding the efficacy of medications has been generated by clinical trials involving patients completely different from those currently admitted to internal medicine: much younger, affected by a single disease and managed in a highly controlled research environment. Because only registries can provide information on drug effectiveness in real-life conditions, REPOSI started in 2008 with the goal of acquiring data on elderly people acutely admitted to medical or geriatric hospital wards in Italy. The main goals of the registry were to evaluate drug prescription appropriateness, the relationship between multimorbidity/polypharmacy and such cogent outcomes as hospital mortality and re-hospitalization, and the identification of disease clusters that most often concomitantly occur in the elderly. The findings of 3-yearly REPOSI runs (2008, 2010, 2012) suggest the following pertinent tasks for the internist in order to optimally handle their elderly patients: the management of multiple medications, the need to become acquainted with geriatric multidimensional tools, the promotion and implementation of a multidisciplinary team approach to patient health and care and the corresponding involvement of patients and their relatives and caregivers. There is also a need for more research, tailored to the peculiar features of the multimorbid elderly patient open Pier Mannuccio Mannucci; Alessandro Nobili; REPOSI Investigators: [...; Mauro Bernardi; Claudio Borghi; Marco Zoli; Luigi Bolondi; Roberto Corinaldesi; Roberto De Giorgio; ...] Pier Mannuccio Mannucci; Alessandro Nobili; REPOSI Investigators: [..; Mauro Bernardi; Claudio Borghi; Marco Zoli; Luigi Bolondi; Roberto Corinaldesi; Roberto De Giorgio; ..]
year | journal | country | edition | language |
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2014-08-28 |