6533b823fe1ef96bd127f6e0
RESEARCH PRODUCT
Synthetic Glycopeptides of the Tandem Repeat Sequence of the Epithelial Mucin MUC4 with Tumour-associated Carbohydrate Antigens
Horst KunzConstanze Brockesubject
chemistry.chemical_classificationTumor-Associated Carbohydrate AntigensChemistryOrganic ChemistryMucinGeneral MedicineMolecular biologyGlycopeptideAmino acidcarbohydrates (lipids)chemistry.chemical_compoundAntigenBiochemistryGalactosamineTandem Repeat SequenceSide chainGlycosylThreoninedescription
Glycohexadecapeptides representing the tandem repeat sequence of the epithelial mucin MUC4 were prepared by applying a solid-phase methodology. The required glycosyl amino acid building blocks containing the tumour-associated saccharide antigens T N -, T,- sialyl-T N , (2,6)- and (2,3)-sialyl-T were synthesized according to a straightforward biomimetic strategy by stepwise extension of the saccharide side chain of a Fmoc-protected galactosamine threonine tert-butyl ester.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-02-17 | Synlett |