6533b823fe1ef96bd127f6f6
RESEARCH PRODUCT
Cell fusion as a mechanism for the formation of giant cells (Langhans’ type)
K. H. LangerW. SonntagW. D. HeineW. Thoenessubject
MalePathologymedicine.medical_specialtyanimal structuresCell fusionurogenital systemChemistryLanghans giant cellGeneral Medicineurologic and male genital diseasesmedicine.diseaseAutoimmune DiseasesRatsCell biologyCell FusionGiant cellRats Inbred BNcardiovascular systemmedicineAnimalsAutoradiographyNephritis InterstitialtissuesNephritisThymidinedescription
The formation of multinuclear giant cells of the Langhans' type in tubulo-interstitial auto-immune nephritis in the rat has been investigated by means of autoradiography. While in the majority of giant cells all nuclei were radiolabeled, in a few both labeled and unlabeled nuclei were present. This latter finding represents strong evidence in favour of the hypothesis that giant cells do not form by endomitotic processes but rather through fusion of certain precursor cells. According to previous studies this precursor cell population consists mainly of epitheloid cells, i.e. modified monocytes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1982-12-01 | Virchows Archiv B Cell Pathology Including Molecular Pathology |