The mycotoxin zearalenone enhances cell proliferation, colony formation and promotes cell migration in the human colon carcinoma cell line HCT116.

6533b823fe1ef96bd127f748

RESEARCH PRODUCT

The mycotoxin zearalenone enhances cell proliferation, colony formation and promotes cell migration in the human colon carcinoma cell line HCT116.

Salwa Abid Haila Abassi Hassen Bacha Micheau Olivier Sarah Shirley Imen Ayed-boussema

subject

0301 basic medicine Bone-Marrow-Cells Aflatoxin Aflatoxin B1 Time Factors [ SDV.TOX ] Life Sciences [q-bio]/Toxicology Toxicology medicine.disease_cause Induction chemistry.chemical_compound 0302 clinical medicine Proliferation assay Cell Movement Zearalenone biology food and beverages Cell migration General Medicine Migration assay Dna-Damage 030220 oncology & carcinogenesis [SDV.TOX]Life Sciences [q-bio]/Toxicology Colonic Neoplasms Zearalenone Chromosome-Aberrations Balb/C Mice Fusarium endocrine system Preventive Role 03 medical and health sciences Botany medicine Humans Neoplasm Invasiveness Mycotoxin Carcinogen Cell Proliferation Wound Healing Dose-Response Relationship Drug Cell growth fungi Clonogenic assay biology.organism_classification HCT116 Cells Molecular biology 030104 developmental biology chemistry Mcf-7 Cells Fusarium Toxins In-Vitro Vitamin-E Carcinogens Genotoxicity

description

IF 3.522; International audience; Zearalenone (ZEN) and Aflatoxin B1 (AFB1) are fungal secondary metabolites produced by Fusarium and Aspergillus genera, respectively. These mycotoxins are found world-wide as corn and wheat contaminants. AFB1 is probably the most toxic and carcinogenic mycotoxin. It has been demonstrated to be mutagenic, genotoxic, and hepatocarcinogenic. ZEN is a non-steroidal estrogenic mycotoxin that displays hepatotoxicity, immunotoxicity and genotoxicity. Its mutagenic and carcinogenic properties have so far remained controversial and questionable. Using the colon carcinoma cell line HCT116, we will show here that ZEN, at low concentrations, enhances cell proliferation, increases colony formation and fastens cell migration after wound healing. The highest effect of ZEN was observed at a concentration 10 times lower as compared to AFB1. Our findings suggest thus that this mycotoxin exhibits carcinogenesis-like properties in HCT116 cells. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

year	journal	country	edition	language
2016-07-08	Toxicology letters

10.1016/j.toxlet.2016.04.012 https://pubmed.ncbi.nlm.nih.gov/27084041