6533b823fe1ef96bd127f74a
RESEARCH PRODUCT
The role of reactive oxygen species in obesity therapeutics.
Antonio Hernández-mijaresSusana Rovira-llopisVictor M. VictorMilagros Rochasubject
Infertilitychemistry.chemical_classificationmedicine.medical_specialtyReactive oxygen speciesEndocrinology Diabetes and MetabolismSleep apneaMitochondrionBiologyBioinformaticsmedicine.diseasemedicine.disease_causeObesityEndocrinologychemistryInternal medicineDiabetes mellitusmedicineRisk factorOxidative stressdescription
Obesity is a major risk factor for multiple severe health conditions, including cardiovascular diseases, diabetes and cancer. It is often related to an increased risk of morbidity and mortality and, as it can be accompanied by non-fatal health problems, quality of life is seriously reduced due to related conditions including hypertension, sleep apnea, osteoarthritis, respiratory problems and infertility. Evidence suggests that oxidative stress is related to obesity and its complications. In obese patients, there is an increase in levels of reactive oxygen species and nitrogen species and antioxidant defenses are undermined in comparison to normal-weight counterparts. In addition, these parameters inversely correlate with central adiposity. In this review, the authors discuss current concepts concerning the relationship between obesity and oxidative stress and mitochondrial impairment. Potential interventions to improve redox balance are also explored.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-02-10 | Expert review of endocrinologymetabolism |