6533b823fe1ef96bd127f7d0

RESEARCH PRODUCT

Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line

Juan J. TarínAntonio CanoBegoña PinedaCarlos EhermenegildoMiguel Angel García-pérez

subject

Cimicifugamedicine.medical_specialtyOsteocalcinCore Binding Factor Alpha 1 SubunitOsteoblastic cellBone and BonesCollagen Type IBone resorptionCell Line2-PropanolMiceOsteogenesisInternal medicinemedicineAnimalsHumansProspective StudiesBone ResorptionOsteoblastsbiologyPlant Extractsbusiness.industryCimicifuga racemosaBone markersObstetrics and GynecologyOsteoblastAlkaline PhosphatasePostmenopauseEndocrinologymedicine.anatomical_structureReproductive MedicineCell cultureOsteocalcinbiology.proteinAlkaline phosphataseFemalePeptidesbusinessBiomarkersPhytotherapy

description

Postmenopausal women treated with an isopropanolic extract of Cimicifuga racemosa underwent a decrease in the urinary concentration of N-telopeptides, a marker of bone resorption, and an increase in alkaline phosphatase, a marker of bone formation, at the third month of therapy. Serum from treated women did not modify the activity of alkaline phosphatase or the expression of three genes, runt-related transcription factor-2 (Runx-2), alkaline phosphatase, and osteocalcin, when added to the MC3T3-E1 osteoblastic cell line.

yearjournalcountryeditionlanguage
2009-04-01Fertility and Sterility
https://doi.org/10.1016/j.fertnstert.2008.03.042