6533b824fe1ef96bd127fed2
RESEARCH PRODUCT
Species-Specific Aggregation Factor in Sponges
Werner E.g. MüllerRudolf K. ZahnBranko KurelecIsabel M. Müllersubject
Siliceous spongeCancer ResearchbiologyGeodia cydoniumBuoyant densityMineralogyCell BiologyCarbohydratebiology.organism_classificationSuberites domunculaBiochemistryGeodiaReceptorMolecular BiologyDevelopmental BiologySuberitesdescription
An aggregation receptor (AR) from the siliceous sponge Suberites domuncula has been isolated and purified by chromatography to about 55% purity. The AR consists primarily of neutral carbohydrate and is characterized by a buoyant density of 1.59 g/ml and by an apparent molecular weight of 42,500. The average density of the AR on Suberite cells is about 3.8 × 10 5 per μm 2 . The AR contains considerable amounts of hexuronic acid. The isolated AR can bind not only to receptor-depleted Suberites cells but also to receptor depleted cells from another siliceous species (Geodia cydontum) . After being charged with Suberites ARs, Geodia cells form aggregates in the presence of the species-specific Suberites aggregation factor.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1978-05-01 | Differentiation |