6533b824fe1ef96bd127ff8f

RESEARCH PRODUCT

Combination of high bolus dose of tirofiban with half dose thrombolytics for the treatment of subacute stent thrombosis

Salvatore PaternaSergio CannizzaroPietro Di Pasquale

subject

Malemedicine.medical_specialtyPercutaneous transluminal coronary angioplastymedicine.medical_treatmentMyocardial InfarctionThrombolysiCoronary AngiographyRisk AssessmentBolus (medicine)Fibrinolytic AgentsCoronary CirculationAcute thrombosiInternal medicineStentmedicineHumanscardiovascular diseasesStent thrombosisMyocardial infarctionAngioplasty Balloon CoronaryVascular PatencyAgedDose-Response Relationship Drugbusiness.industryCoronary ThrombosisGeneral MedicineTirofibanThrombolysismedicine.diseaseThrombosisSurgeryTirofibanBypass surgeryAcute DiseaseCardiologyTyrosineDrug Therapy CombinationStentsCardiology and Cardiovascular MedicinebusinessFollow-Up Studiesmedicine.drug

description

Acute stent thrombosis is rare and it is usually related to complications during the procedure. Subacute thrombosis is far more common and is associated with a high incidence of acute myocardial infarction and death. Restoration of flow by thrombolysis, emergency bypass surgery or emergency percutaneous transluminal coronary angioplasty (PTCA) has had only limited success with respect to myocardial salvage. We report the case of a patient who suffered from recurrent subacute stent thrombosis, in whom administration of tirofiban at high-dose bolus in association with a half dose of recombinant tissue plasminogen activator succeeded in restoring normal myocardial flow and stable clinical condition.

yearjournalcountryeditionlanguage
2005-03-23Acta Cardiologica
https://doi.org/10.2143/ac.60.1.2005052