6533b824fe1ef96bd127ffd3

RESEARCH PRODUCT

Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus.

S PuzelliM FacchiniD Spagnolo De Marco MaL CalzolettiA ZanettiR FumagalliMl TanziA CassoneG RezzaI DonatelliSurveillance Group For Pandemic A. H1n1 2009 Influenza Virus In ItalyPierlanfranco D'agaro

subject

MaleEpidemiologyvirusesMutantResistancelcsh:MedicineHemagglutinin Glycoproteins Influenza VirusSettore MED/42 - Igiene Generale E Applicatamedicine.disease_causeSeverity of Illness IndexDisease Outbreakschemistry.chemical_compoundInfluenza A Virus H1N1 SubtypePandemicInfluenza A virusA/H1N1PhylogenyTransmission (medicine)H1N1DispatchtransmissionMiddle AgedInfectious DiseasesD222GItalyInfluenza A virusRNA ViralinfluenzaMicrobiology (medical)AdultOseltamivirMutation MissenseHemagglutinin (influenza)BiologyViruslcsh:Infectious and parasitic diseasesMicrobiologyOseltamivirInfluenza HumanmedicineHumanslcsh:RC109-216virusesRetrospective StudiesAntiserumSequence Analysis RNApandemiclcsh:RMutantVirologyInfluenzaH1N1 subtypechemistryAmino Acid Substitutionbiology.proteinA/H1N1vmutationInfluenza; A/H1N1v; Oseltamivir; Resistance

description

A pandemic (H1N1) 2009 virus strain carrying the D222G mutation was identified in a severely ill man and was transmitted to a household contact. Only mild illness developed in the contact, despite his obesity and diabetes. The isolated virus reacted fully with an antiserum against the pandemic vaccine strain.

yearjournalcountryeditionlanguage
2010-05-01Emerging infectious diseases
10.3201/eid1605.091815https://pubmed.ncbi.nlm.nih.gov/20409386