6533b824fe1ef96bd1280033

RESEARCH PRODUCT

Chronological Age Interacts with the Circadian Melatonin Receptor 1B Gene Variation, Determining Fasting Glucose Concentrations in Mediterranean Populations. Additional Analyses on Type-2 Diabetes Risk

José I. GonzálezRocío BarragánJosé V SorlíOlga PortolésJose M. OrdovasDolores CorellaAlejandro Pérez-fidalgoCarmen SaizCarolina Ortega-azorínEva C. PascualOscar ColtellRamon Estruch

subject

Blood GlucoseMale0301 basic medicinePhysiologyType 2 diabetestype-2 diabetesDiabetis no-insulinodependentMediterranean population0302 clinical medicineRisk FactorsPolymorphism (computer science)MedicineNon-insulin-dependent diabetesmelatonin receptorAged 80 and overeducation.field_of_studyNutrition and DieteticsMediterranean RegionAge FactorsDiabetis en l'embaràsFastingMiddle AgedGestational diabetesMTNR1B polymorphismCohortFemalepregnancywomengestational diabeteslcsh:Nutrition. Foods and food supplyage-interactionhormones hormone substitutes and hormone antagonistsAdultDiabetes riskAdolescentPopulationlcsh:TX341-641030209 endocrinology & metabolismPolymorphism Single NucleotideRisk AssessmentArticleYoung Adult03 medical and health sciencesDiabetes mellitusHumanseducationAgedRetrospective StudiesReceptor Melatonin MT2business.industrymedicine.diseaseCross-Sectional Studies030104 developmental biologyDiabetes Mellitus Type 2Melatonin receptor 1BSpainheterogeneitybusinessDiabetes in pregnancyfasting glucoseFood Science

description

Gene-age interactions have not been systematically investigated on metabolic phenotypes and this modulation will be key for a better understanding of the temporal regulation in nutrigenomics. Taking into account that aging is typically associated with both impairment of the circadian system and a decrease in melatonin secretion, we focused on the melatonin receptor 1B (MTNR1B)-rs10830963 C&gt

yearjournalcountryeditionlanguage
2020-10-29Nutrients
10.3390/nu12113323http://dx.doi.org/10.3390/nu12113323