6533b824fe1ef96bd128014e
RESEARCH PRODUCT
Memantine does not block antiaggressive effects of morphine in mice.
Marta Rodríguez-ariasJosé MiñarroMaría A. AguilarC. Maldonadosubject
PharmacologyMaleNarcoticsMorphinebusiness.industryMemantinePharmacologyReceptors N-Methyl-D-AspartateAggressionPsychiatry and Mental healthGlutamatergicMiceMemantineAdaptation PsychologicalMorphineMedicineNMDA receptorAnimalsbusinessExcitatory Amino Acid Antagonistsmedicine.drugdescription
The action of the noncompetitive N-methyl-D-aspartate (NMDA) receptor blocker memantine (5, 10, 20 and 40 mg/kg) was evaluated during social encounters in mice. Although a dose-dependent increase in locomotion was observed, only with the highest dose did it reach statistical significance. Aggressive behavior was decreased with 20 and 40 mg/kg of memantine, social contacts being increased only with 20 mg/kg. Subsequently, the effect of these memantine doses on the antiaggressive actions of morphine (10 mg/kg) was evaluated. None of the doses affected the antiaggressive action of morphine. As memantine administration produced an antiaggressive effect only at doses that affected locomotion, it is unlikely that the glutamatergic system mediates the antiaggressive actions of morphine.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-07-18 | Behavioural pharmacology |