6533b824fe1ef96bd12801f3
RESEARCH PRODUCT
Cytotoxic properties of Marrubium globosum ssp. libanoticum and its bioactive components
Felice SenatoreFilomena ConfortiMariangela MarrelliMaurizio BrunoDaniela RiganoFrancesco MenichiniCarmen Formisanosubject
PharmacologybiologyTraditional medicineChemistryCytotoxicityPlant ScienceGeneral MedicineSettore CHIM/06 - Chimica OrganicaMarrubium globosum Lebanon antiproliferative activitybiology.organism_classificationLabdane diterpenoidPhenolic compoundsComplementary and alternative medicineDrug DiscoveryMarrubium globosum libanoticumCytotoxic T cellSettore BIO/15 - Biologia FarmaceuticaMelanomaMarrubiumdescription
Marrubium globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae) is a medicinal plant used in Lebanon for the treatment of inflammatory diseases, asthma, coughs and other pulmonary and urinary problems. The goal of our study was to assess the biological activity of M. globosum by testing different extracts of the aerial parts for their antiproliferative activity against human melanoma cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The chloroform fraction showed the greatest activity. The compounds isolated from the extracts were also tested: the mixture of (13 S)-9α,13α-epoxylabda-6β(19),16(15)-diol dilactone and (13 R)-9α,13α-epoxylabda-6β(19),16(15)-diol dilactone was the most active fraction, with an IC50 value of 29.2 ± 0.06 μg/mL.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-05-01 |