6533b824fe1ef96bd128025f
RESEARCH PRODUCT
Remission of severe rheumatoid arthritis following liver transplantation.
Thomas PorallaG. OttoAw LohseK H Meyer Zum BüschenfeldeElisabeth Hermannsubject
AdultMalemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentRemission SpontaneousArthritisLiver transplantationAsymptomaticGastroenterologyArthritis RheumatoidFulminant hepatic failureRheumatologyPirprofenInternal medicinemedicineHumansPharmacology (medical)HepatitisPhenylpropionatesbusiness.industrymedicine.diseaseSurgeryLiver TransplantationTransplantationRheumatoid arthritismedicine.symptomChemical and Drug Induced Liver InjurybusinessImmunosuppressive Agentsmedicine.drugFollow-Up Studiesdescription
We present the case of a 32-year-old male who suffered from severe RA from the age of 21 years. After 9 years of active disease and poor response to therapy the patient developed severe hepatitis induced by the NSAID pirprofen. He went into fulminant hepatic failure necessitating emergency liver transplantation. Liver transplantation was followed by clinical and laboratory remission of his RA and he has remained virtually asymptomatic for more than 3.5 years. The possibility that this favourable clinical course was due to the immunosuppressive effect of the liver transplant rather than the ensuing immunosuppressive therapy is discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-09-01 | British journal of rheumatology |