6533b824fe1ef96bd1280295
RESEARCH PRODUCT
New antifungals selected by molecular topology.
S. WolskiJorge GalvezL. PastorM.d. Garcı́aRamón García-domenechsubject
Antifungal AgentsMolecular modelStereochemistryClinical BiochemistryBiphenyl derivativesPharmaceutical ScienceMicrobial Sensitivity TestsSaccharomyces cerevisiaeBiochemistryChloridechemistry.chemical_compoundStructure-Activity RelationshipDrug DiscoveryCandida albicansmedicineMolecular BiologyTopology (chemistry)Organic ChemistryDiscriminant AnalysisBiphenylenechemistryDrug DesignMolecular MedicineBenztropine MesylateMolecular topologymedicine.drugdescription
Abstract Molecular topology has been applied to find the new lead antimycotic compounds. Among the selected compounds stands out 3,3′-(4,4′ - Biphenylene)bis(2,5-diphenyl-2H-tetrazolium chloride), Benztropine mesylate and Dicyclopentamethylenethiuram disulphide, with minimum inhibitory concentrations between 1.6 and 2 μg / mL.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-01-05 | Bioorganicmedicinal chemistry letters |