0000000000544716

AUTHOR

M.d. Garcı́a

showing 2 related works from this author

New antifungals selected by molecular topology.

1999

Abstract Molecular topology has been applied to find the new lead antimycotic compounds. Among the selected compounds stands out 3,3′-(4,4′ - Biphenylene)bis(2,5-diphenyl-2H-tetrazolium chloride), Benztropine mesylate and Dicyclopentamethylenethiuram disulphide, with minimum inhibitory concentrations between 1.6 and 2 μg / mL.

Antifungal AgentsMolecular modelStereochemistryClinical BiochemistryBiphenyl derivativesPharmaceutical ScienceMicrobial Sensitivity TestsSaccharomyces cerevisiaeBiochemistryChloridechemistry.chemical_compoundStructure-Activity RelationshipDrug DiscoveryCandida albicansmedicineMolecular BiologyTopology (chemistry)Organic ChemistryDiscriminant AnalysisBiphenylenechemistryDrug DesignMolecular MedicineBenztropine MesylateMolecular topologymedicine.drugBioorganicmedicinal chemistry letters
researchProduct

Molecular topology: a useful tool for the search of new antibacterials.

2000

Molecular topology has been applied to find new lead antibacterial compounds. Among the selected compounds, hesperidin, neohesperidin and Mordant Brown 24 stand out, with minimum inhibitory concentrations 90, MIC90<0.3 mg / mL.

chemistry.chemical_classificationNeohesperidinMolecular modelBacteriamedicine.drug_classStereochemistryOrganic ChemistryClinical BiochemistryAntibioticsFlavonoidPharmaceutical ScienceMordantBiochemistryCombinatorial chemistryAnti-Bacterial AgentsHesperidinchemistry.chemical_compoundchemistryDrug DiscoverymedicineMolecular MedicineMolecular BiologyTopology (chemistry)Antibacterial agentBioorganicmedicinal chemistry letters
researchProduct