Synthesis of activated cyclophosphamide derivatives bearing functional groups

6533b824fe1ef96bd12808db

RESEARCH PRODUCT

Synthesis of activated cyclophosphamide derivatives bearing functional groups

Wolfgang Klesse Gabriele Lambert Joerg H. Heusinger Takashi Hirano Helmut Ringsdorf

subject

Cyclophosphamide Chemistry Stereochemistry Organic Chemistry Drug Discovery medicine Organic chemistry Biochemistry medicine.drug

description

Aus Cyclophosphamid (I) erhalt man mit Ozon das Hydroperoxid (IIa), das mit Triethylphosphit zu (IIb) reduziert und dann in Trifluoressigsaure mit entsprechenden Thioverbindungen zu zahlreichen Thioethern (III) mit funktionellen Gruppen substituiert werden kann . Diese werden auf Antitumorwirkung untersucht.

year	journal	country	edition	language
1979-01-01	Tetrahedron Letters

https://doi.org/10.1016/s0040-4039(01)93578-6

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