6533b824fe1ef96bd1280a96
RESEARCH PRODUCT
Association between +1059G/C CRP polymorphism and acute myocardial infarction in a cohort of patients from Sicily: a pilot study.
Enrico HoffmannGiuseppina Colonna-romanoMaria Paola GrimaldiGiuseppina CandoreCarmela Rita BalistreriCalogero CarusoFlorinda ListìMarco CarusoDomenico LioGregorio CaimiSonya Vastosubject
AdultMalemedicine.medical_specialtyPopulationMyocardial InfarctionPilot ProjectsGastroenterologyPolymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologyPathogenesisCohort StudiesHistory and Philosophy of ScienceGene FrequencyInternal medicinemedicineImmunogeneticsOdds RatioSNPHumansMyocardial infarctioneducationSicilyInflammationeducation.field_of_studyPolymorphism Geneticbusiness.industryGeneral NeuroscienceCase-control studyOdds ratioMiddle Agedmedicine.diseaseSurgeryC-Reactive ProteinCase-Control StudiesCohortAcute DiseasebusinessCohort studydescription
Inflammation plays a role in all the phases of atherosclerosis, and increased production of the acute-phase reactant, C-reactive protein (CRP), predicts future cardiovascular events. Furthermore, CRP has been claimed to play a role in the pathogenesis of atherosclerosis; therefore, CRP polymorphisms might be associated with acute myocardial infarction (AMI). We have analyzed male patients affected by AMI and healthy age-related male controls from Sicily for +1059G/C CRP single-nucleotide polymorphism (SNP). There was a significantly higher frequency of +1059C SNP (P = 0.0008; OR 3.86) in patients compared to controls. CRP serum levels were significantly higher in C+ healthy subjects rather than in C- subjects (P = 0.0075). The results of the present pilot case-control study performed in a homogeneous caucasoid population suggest that +1059C CRP gene SNP is associated with AMI. In any case, the results of the present study should add to the growing body of evidence on the role of pro-inflammatory genotypes in unsuccessful aging, determining susceptibility to immune-inflammatory diseases such as coronary heart disease.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-06-29 | Annals of the New York Academy of Sciences |