6533b824fe1ef96bd1280a99

RESEARCH PRODUCT

Circulating immune complexes and platelet thromboxane synthesis in patients with insulin-dependent (type I) diabetes mellitus

Francesco MeliGiovanni DavìF. CardellaGiovani TrioloE GiardinaA. La GruttaBompiani GdA. Strano

subject

Blood PlateletsMalemedicine.medical_specialtyThromboxaneInsulin AntibodiesEndocrinology Diabetes and MetabolismAntigen-Antibody ComplexPathogenesisImmune systemInternal medicineDiabetes mellitusmedicineInternal MedicineHumansPlateletIn patientChildbusiness.industryMicroangiopathyThromboxanesComplement C3medicine.diseaseImmune complexAntibodies Anti-IdiotypicThromboxane B2Diabetes Mellitus Type 1EndocrinologyImmunoglobulin GImmunologyFemalebusiness

description

Platelets from diabetic subjects with circulating immune complexes (CIC) synthesized greater amounts of thromboxane than did platelets from CIC-negative patients or controls. In view of the known action of CIC on platelet function, a relationship between these two factors may be suggested in the initiation and progression of microangiopathy in diabetes.

yearjournalcountryeditionlanguage
1984-08-01Diabetes
https://doi.org/10.2337/diabetes.33.8.728