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RESEARCH PRODUCT

Long term hemodialysis aggravates lipolytic activity reduction and very low density, low density lipoproteins composition in chronic renal failure patients.

Josiane ProstKhedidja MekkiMalika BouchenakJacques BellevilleMustapha Remaoun

subject

AdultMalelcsh:Diseases of the circulatory (Cardiovascular) systemVery low-density lipoproteinmedicine.medical_specialtyTime Factorsmedicine.medical_treatmentLipolysisBlood lipidsLipoproteins VLDLRisk Assessmentchemistry.chemical_compoundRenal DialysisRisk FactorsInternal medicinemedicineHumansInsulinLongitudinal StudiesTriglyceridesDyslipidemiasLipoprotein lipaseApolipoprotein C-IIICholesterolbusiness.industryHypertriglyceridemianutritional and metabolic diseasesLipaseMiddle Agedmedicine.diseaseAtherosclerosisLipoproteins LDLLipoprotein LipaseEndocrinologyCholesterolchemistrylcsh:RC666-701Low-density lipoproteinLinear ModelsKidney Failure Chroniclipids (amino acids peptides and proteins)Apolipoprotein C-IIFemaleHepatic lipaseHemodialysisCardiology and Cardiovascular MedicinebusinessBiomarkersResearch Article

description

Abstract Background Dyslipidemia, particularly hypertriglyceridemia is common in uremia, and represents an independent risk factor for atherosclerosis. Methods To investigate the effects of hemodialysis (HD) duration on very low density lipoprotein (VLDL) and low density lipoprotein (LDL) compositions and lipopolytic activities, 20 patients on 5 to 7 years hemodialysis were followed-up during 9 years. Blood samples were drawn at T0 (beginning of the study), T1 (3 years after initiating study), T2 (6 years after initiating study) and T3 (9 years after initiating study). T0 was taken as reference. Results Triacylglycerols (TG) values were correlated with HD duration (r = 0.70, P Conclusion Despite hemodialysis duration, VLDL-LDL metabolism alterations are aggravated submitting patients to a greater risk of atherosclerosis.

yearjournalcountryeditionlanguage
2009-08-01BMC cardiovascular disorders
10.1186/1471-2261-9-41https://pubmed.ncbi.nlm.nih.gov/19709414